What is low molecular weight hyaluronic acid?

Low molecular weight hyaluronic acid and its role in maintaining healthy and beautiful skin

Hyaluronic acid is a natural component of human tissue. The skin is the main depot of hyaluronic acid in the human body and contains more than half of the entire reserve of this component. In the skin, hyaluronic acid, as an active component, is found in the intercellular and intracellular spaces and performs a number of functions: it retains water, thereby maintaining the natural elasticity and volume of tissues; it participates in the renewal of structural skin cells and immune cells, thereby playing a role in maintaining normal skin growth and renewal and strengthening collagen fibers. An important physiological property of hyaluronic acid in the skin is its support of local immunity. It helps skin cells act as a natural barrier against pathogens, chemicals, and free radicals (molecules that damage the skin).

A deficiency of natural hyaluronic acid, such as that caused by aging or skin diseases, leads to pathological and age-related changes in the skin: decreased local immunity, wound healing ability, and skin elasticity. Clinically, this is expressed in skin aging, which leads to the appearance of wrinkles.

Types of Hyaluronic Acid

Currently, three types of hyaluronic acid are used in cosmetics: high-molecular, medium-molecular, and low-molecular. High-molecular hyaluronic acid is capable of retaining water only on the surface of the skin, in the very top layer. The molecules of this type of hyaluronic acid are large enough to penetrate the topmost layer of skin but have low penetrating power, so they cannot replenish the amount of hyaluronic acid in the deeper layers of the skin. Low-molecular-weight hyaluronic acid has the most pronounced penetrating power (compared to medium-molecular-weight, for example) in tissue due to its low weight and small molecule size. This type of hyaluronic acid penetrates the deep layers of the skin, moisturizing it and enhancing natural regeneration (cell renewal).

Hyaluronic Acid Production

It should be noted that in nature, hyaluronic acid is found not only in the human body, but also in the bodies of mammals, birds, and in the microorganisms that surround us. Since the discovery of hyaluronic acid as a chemical compound in 1934 and up to the present day, more than 15,000 scientific articles on hyaluronic acid have been published worldwide, dedicated to its properties, biological effects, production, isolation and application.
The production of hyaluronic acid for subsequent use in medicine, including aesthetics, and in cosmetics is a high-tech process that requires large material costs. All known methods for obtaining hyaluronic acid can be divided into two groups:
1. The physicochemical method, which consists of isolating hyaluronic acid from the tissues of mammals, other vertebrates and birds;
2. Microbial method for producing hyaluronic acid using bacterial producers.
In recent decades, the physicochemical method has become widespread for the industrial production of hyaluronic acid. Cockscombs, pig skins, and cartilage are used as raw materials to isolate hyaluronic acid. The raw materials are crushed, purified, and the active component is isolated.

A more modern and high-tech method is the microbial synthesis of hyaluronic acid using bacterial producer strains. This biotechnological method allows for the production of highly purified hyaluronic acid, free from harmful impurities, and, accordingly, with low allergenicity. Accordingly, hyaluronic acid obtained by this method has stronger anti-inflammatory, immunomodulatory, and long-lasting effects. Low-molecular-weight hyaluronic acid is most often synthesized using this method, and it also has a scientifically proven significant angiogenic effect: it increases the number of vessels in tissues, improves microcirculation, and reduces inflammation.
Skin care products containing low-molecular-weight hyaluronic acid are considered the most effective, as low-molecular-weight hyaluronic acid is not found in all commercially available skin care lines due to the high-tech, cost-intensive production process. An example of a highly effective cosmetic line for daily comprehensive skin care, which contains low molecular weight hyaluronic acid in each product, is the Hyaluronic line of products from the pharmacy brand LIBREDERM. 

LIBREDERM Hyaluronic Moisturizing Standard: 2 Steps

The cosmetic brand LIBREDERM has developed a hyaluronic moisturizing standard, consisting of two steps and meeting the highest standards of moisturizing the skin of all types: Step 1 - cleansing the skin, the second - basic care. 

Step 1. Cleansing

The first step is cleansing the skin with the help ofhyaluronic foamfor washing orgommage gel.
If the skin needs deep cleansing, after washing you can usepeeling rollorfacial scrub.

Step 2. Basic care

Step 1. Toning. The second stage begins with toning the skin with hyaluronicmoisturizing toner.
Stage 2. Intensive care. When the skin is prepared for the application of basic care products, the ideal moment has come for intensive care usinghyaluronic activator serum.
Stage 3. Basic care.Hyaluronic cream for face, neck and décolleté“seals” the serum and completes the care ritual. In addition to it, you can usea broad-spectrum eye cream, as well asHydrobalance night cream— for skin care before bed. 

Each product in the line contains high-quality low-molecular hyaluronic acid in the required concentration, obtained using advanced microbial synthesis technologies. The distinctive qualities of the LIBREDERM hyaluronic collection are versatility (the products are suitable for any skin type), comprehensiveness (the collection includes products that satisfy all skin needs), hypoallergenicity, and a prolonged moisturizing effect. Thanks to this, care based on the products in the collection allows you to maintain the health, youth, and beauty of your skin.

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